Obstetrical complications and subsequent schizophrenia in adolescent and young adult offsprings: is there a relationship?
Identifieur interne : 000307 ( France/Analysis ); précédent : 000306; suivant : 000308Obstetrical complications and subsequent schizophrenia in adolescent and young adult offsprings: is there a relationship?
Auteurs : Georges Boog [France]Source :
- European journal of obstetrics, gynecology, and reproductive biology [ 0301-2115 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- épidémiologie : Schizophrénie.
- Pascal (Inist)
- Adolescent, Adulte, Complications de la grossesse, Femelle, Grossesse, Humains, Maladies virales, Schizophrénie, Complication, Adolescent, Adulte jeune, Descendance, Souffrance foetale, Stress psychologique, Supplémentation, Prénatal, Stress, Mère, Dénutrition, Gynécologie, Obstétrique, Troubles nutritionnels.
- Wicri :
- topic : Gynécologie.
English descriptors
- KwdEn :
- Adolescent, Adult, Complication, Denutrition, Female, Fetal Distress, Gynecology, Humans, Mother, Nutrition Disorders (complications), Obstetrics, Pregnancy, Pregnancy Complications, Prenatal, Progeny, Schizophrenia, Schizophrenia (epidemiology), Stress, Stress, Psychological (complications), Supplementation, Virus Diseases (complications), Young adult.
- MESH :
- complications : Nutrition Disorders, Stress, Psychological, Virus Diseases.
- epidemiology : Schizophrenia.
- Adolescent, Adult, Female, Fetal Distress, Humans, Pregnancy, Pregnancy Complications.
Abstract
Schizophrenia is a psychiatric disease affecting around 1% of the population, the negative signs of which are correlated with inactivity of the prefrontal dorsolateral cortex, while an increased, more deeply localized, activity in the mesolimbic pathway may explain the positive signs Several events occurring during pregnancy are likely to be involved in its genesis: hormonal supplementation by diethylstilbestrol. severe maternal denutrition, exposure to influenza virus, repeated psychological stress. From multicentric studies and meta-analyses in the psychiatric literature, the risk of schizophrenia appears to he multiplied by two if pregnancy is complicated, mainly by diabetes, Rhesus incompatibility, bleeding, preeclampsia, premature rupture of membranes and preterm birth. When delivery is linked to an abnormal presentation or happens via a caesarean birth for acute foetal distress the time when the first signs of psychosis appear seems to be earlier in adolescence or in early adulthood. Cerebral imaging of schizophrenic patients shows ventriculomegaly and gray matter reduction, mainly in hippocampal volumes and in the dorsolateral prefrontal cortex. Similar alterations in the neuronal pathways have been experimentally reproduced in rats after repeated prenatal stress and perinatal hypoxia, A region on the distal portion of chromosome I has shown evidence for linkage to schizophrenia. Therefore, a two factor model seems to be able to explain the onset of schizophrenia in which obstetrical complications may interact with a genetic liability and in which the consequences of hypoxic events may lie on a continuum ranging from cerebral palsy in some children to subtle cognitive and behavioural disturbances in others.
Affiliations:
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Pascal:04-0287737Le document en format XML
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type="topic" xml:lang="fr"><term>Gynécologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Schizophrenia is a psychiatric disease affecting around 1% of the population, the negative signs of which are correlated with inactivity of the prefrontal dorsolateral cortex, while an increased, more deeply localized, activity in the mesolimbic pathway may explain the positive signs Several events occurring during pregnancy are likely to be involved in its genesis: hormonal supplementation by diethylstilbestrol. severe maternal denutrition, exposure to influenza virus, repeated psychological stress. From multicentric studies and meta-analyses in the psychiatric literature, the risk of schizophrenia appears to he multiplied by two if pregnancy is complicated, mainly by diabetes, Rhesus incompatibility, bleeding, preeclampsia, premature rupture of membranes and preterm birth. When delivery is linked to an abnormal presentation or happens via a caesarean birth for acute foetal distress the time when the first signs of psychosis appear seems to be earlier in adolescence or in early adulthood. Cerebral imaging of schizophrenic patients shows ventriculomegaly and gray matter reduction, mainly in hippocampal volumes and in the dorsolateral prefrontal cortex. Similar alterations in the neuronal pathways have been experimentally reproduced in rats after repeated prenatal stress and perinatal hypoxia, A region on the distal portion of chromosome I has shown evidence for linkage to schizophrenia. Therefore, a two factor model seems to be able to explain the onset of schizophrenia in which obstetrical complications may interact with a genetic liability and in which the consequences of hypoxic events may lie on a continuum ranging from cerebral palsy in some children to subtle cognitive and behavioural disturbances in others.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement></list><tree><country name="France"><region name="Pays de la Loire"><name sortKey="Boog, Georges" sort="Boog, Georges" uniqKey="Boog G" first="Georges" last="Boog">Georges Boog</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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